The Mekong Delta, Vietnam is one of the largest river deltas in the world with 39.712 km2 and home to over 18 million inhabitants. It is located in the lower Mekong River, which originates at the Tibetan plateau and crosses China, Myanmar, Laos, Thailand, and Cambodia before entering the territory of Vietnam. The delta was formed by the deposition of sediments from the Mekong River over thousands of years. It is considered as a rice bowl of the whole country with a contribution approximately 52% of the national rice production, and 70% of national rice exportation, putting Vietnam at the second place in the world rice market. With an area of only about 5% of the total catchment area of the Mekong River and low natural ground (mostly below +2m a.s.l.), the Mekong delta is annually impacted by flooding from the upper part of the delta. Extreme land-use occupation for rice intensification in the upper provinces of Mekong Delta in recent years with double and/or triple rice cropping, has been significantly influencing the seasonal flood regime of the Delta.Due to progressive poldering of the flood plains (to protect the rice crops from flood waters), the flood plains are increasingly restricted. In this line, the present study is aimed at analyzing the impacts of land-use change to flooding situation in the Mekong delta based on hydraulic modeling and satellite products.